Sridhar Hariharaputran joined the PhD program in January 2005. His thesis supervisor is Prof. Ralf Hofestädt at the Bioinformatics/Medical Informatics Department at Bielefeld University.
Prior to joining the PhD program he was working in the lab of Dr. Nagasuma Chandra at Indian Institute of Science , Bangalore, India and at National Centre for Biological Sciences with Dr. Upinder Bhalla, Bangalore, India after obtaining the Master of Science (M.Sc.) degree from the University of Madras, Chennai, India.
Research
Thesis focus - Analysis and representation of complex biological data
Signaling pathways play a major role in cellular processes. In short, from cell birth to cell death, involving lot of complexity but functioning with robustness. Sometimes perturbations in these pathways lead to disease such as cancer. His PhD project focuses on the development of new applications such as algorithms for alignment and prediction of biological pathways, developing integrated database information systems and Modeling and simulation of pathways using Petri nets.
Research interests
Sridhar Hariharaputran is interested in Modeling and simulation of biological pathways, Docking studies, Protein structure visualization, Systems biology, Drug design and disease, Chemo informatics, Homology modeling of protein structures, Algorithms and in Data integration and visualization, Petri nets.
Publication
Sivakumaran S, Hariharaputran S, Mishra J, Bhalla US.
The Database of Quantitative Cellular Signaling: management and analysis of chemical kinetic models of signaling networks.
Bioinformatics. 2003 Feb 12;19(3):408-15.
Kumar P, Rao AG, Hariharaputran S, Chandra N, Gowda LR.
Molecular mechanism of dimerization of Bowman-Birk inhibitors. Pivotal role of ASP76 in the dimerzation.
J Biol Chem. 2004 Jul 16;279(29):30425-32.
Prasad T, Subramanian T, Hariharaputran S, Chaitra HS, Chandra N.
Extracting hydrogen-bond signature patterns from protein structure data.
Appl Bioinformatics. 2004;3(2-3):125-35.
Chaitra MG, Hariharaputran S, Chandra NR, Shaila MS, Nayak R.
Defining putative T cell epitopes from PE and PPE families of proteins of Mycobacterium tuberculosis with vaccine potential.
Vaccine. 2005 Jan 26;23(10):1265-72.
The NMITLI - BioSuite team
BioSuite: A comprehensive bioinformatics software package (A unique industry academia collaboration)
Current Science, Vol.92, No 1, 10 Jan 2007, 29-38
Sivapriya K, Hariharaputran S, Suhas VL, Chandra N, Chandrasekaran S.
Conformationally locked thiosugars as potent alpha-mannosidase inhibitors: Synthesis, biochemical and docking studies.
Bioorg Med Chem. 2007 Sep 1;15(17):5659-65.
Hariharaputran S*, Töpel T, Brockschmidt B and Hofestädt R.
VINEdb: a data warehouse for integration and interactive exploration of life science data.
Journal of Integrative Bioinformatics, 4(3), 2007.
Hariharaputran S*, Töpel T, Oberwahrenbrock T and Hofestädt R
Alignment of Linear Biochemical Pathways Using Protein Structural Classification.
Nature Precedings,doi:10.1038/npre.2008.1943.1(2008).
Conference presentation
Hariharaputran S*, Chen M and Hofestädt R.
Alignment and classification of signaling pathways
In Proceedings of German Conference on Bioinformatics (GCB 2005), Hamburg, 5 - 7 October 2005. (Poster No. 16)
Hariharaputran S* and Töpel T.
A Tool for Alignment and Prediction of Signaling Pathways
In Proceedings of German Conference on Bioinformatics (GCB 2006), Tübingen, 20 - 22 September 2006. (Poster - D8)
Hariharaputran S* and Töpel T. (oral presentation)
Structure-based alignment of linear biochemical pathways.
In Proceedings of Computational Insights into Biological Systems, Bangalore, India, 26 -28 December 2006. (Selected abstract)
Hariharaputran S*, Töpel T, Oberwahrenbrock T and Hofestädt R. (platform presentation)
SignAlign: prediction and alignment of biochemical pathways using protein structural information
In Proceedings of 5th International Conference on Pathways, Networks and Systems, Porto Heli, Greece, 24 - 29 June 2007. (Selected abstract)
Hariharaputran S.(talk)
Bio-silico systems
8th Meeting German / Russian Virtual Network on Computational Systems Biology 5 - 6 November 2007, Germany.
Hariharaputran S, Hofestädt R, Kormeier B, Spangardt S.
MOdeling and VIsualisation of Pathways using Petri Nets.
In Proceedings of the Sixth International Conference on Bioinformatics of Genome Regulation and Structure (BGRS'2008), Novosibirsk, Russia, June 22-28, 2008. (Poster - B5)
Hariharaputran S, Hofestädt R, Kormeier B, Spangardt S.
Modelling and Visualisation of Pathways using Petri Nets.
In Proceedings of the 5th International Symposium on Integrative Bioinformatics, Wittenberg, Germany, August 20 - 22, 2008. (Poster No.70)
Hariharaputran S. (talk)
Petri Net Based Reconstruction And Visualization Of Biochemical Pathways Using Integrated Molecular Data.
Sino-German-Russian Workshop: Metabolic Network Analysis, August 25 - 26, 2008, Bielefeld, Germany
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