Publications
Patents, Disclosures | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 |
Publications in 2010 Publications in 2009 Publications in 2008 Publications in 2007 Publications in 2006 Publications in 2005 Publications in 2004 Publications in 2003 Publications in 2002 Publications in 2001 Publications in 2000 Publications in 1999 Publications in 1998 Publications in 1997 Publications in 1996 Publications in 1995 Publications in 1994 Publications in 1993 Publications in 1992 Publications in 1991 Patents & Disclosures
U. Beshay, G. Miksch, E. Flaschel Screening for conditions of enhanced production of a recombinant β-glucanase secreted into the medium by Escherichia coli.
Biotechnol. Letters 32(2) (2010) 243
B. Santek, M. Felski, K. Friehs, M. Lotz, E. Flaschel Production of paramylon, a β-1,3-glucan, by heterotrophic cultivation of Euglena gracilis on potato liquor.
Eng. Life Sci. 10(2) (2010) 165-170
B. Sommer, K. Friehs, E. Flaschel Efficient production of extracellular proteins with Escherichia coli by means of optimized coexpression of bacteriocin release proteins
J. Biotech. 145 (2010) 350–358
C. Vijayendran, E. Flaschel Impact of profiling technologies in the understanding of recombinant protein production.
Adv. Biochem. Eng./Biotech. 121 (2010) 45-70
S. Burgemeister, T. W. Nattkemper, T. Noll, R. Hoffrogge, E. Flaschel CellViCam - Cell viability classification for animal cell cultures using dark field micrographs.
J. Biotech. 149 (2010) 310-316
B. Sommer, K. Friehs, E. Flaschel, M. Reck, F. Stahl, T. Scheper Extracellular production and affinity purification of recombinant proteins with Escherichia coli using the versatility of the maltose binding protein.
J. Biotech. 140 (2009) 194–202
B. Santek, M. Felski, K. Friehs, M. Lotz, E. Flaschel Production of paramylon, a β-1,3-glucan, by heterotrophic cultivation of Euglena gracilis on a synthetic medium.
Eng. Life Sci. 9(1) (2009) 23-28
U. Beshay, G. Miksch, K. Friehs, E. Flaschel Integrated bioprocess for the production and purification of recombinant proteins by affinity chromatography in Escherichia coli.
Bioprocess Biosyst. Eng. 32 (2009) 149-158, 159
G. Miksch, S. Ryu, J.M. Risse, E. Flaschel
Factors that influence the extracellular expression of streptavidin in Escherichia coli using a bacteriocin
release protein.
Appl. Microbiol. Biotechnol. 81 (2008) 319-326
Ning Wei, E. Flaschel, K. Friehs, T. W. Nattkemper
A machine vision system for automated non-invasive assessment of cell viability via dark field microscopy,
wavelet feature selection and classification. BMC Bioinformatics
BMC Bioinformatics 2008, 9:449 doi:10.1186/1471-2105-9-449
N. Streitner, C. Voß, E. Flaschel
Isolierung von Plasmid-DNA durch inversmizellare Zweiphasensysteme - Optimierung der Rückextraktion.
Chem. Ing. Tech. 80 (2008) 831-837
C. Voß
Aufarbeitung von Plasmid-DNA für Gentherapie und genetische Impfung.
Chem. Ing. Tech. 80 (2008) 795-802
C. Voß
Downstream processing of plasmid DNA for genetherapy and genetic vaccination.
Chem. Eng. Techn. 31 (2008) 858-863
U. Beshay, G. Miksch, K. Friehs, E. Flaschel
Integration von Kultivierung und Aufarbeitung.
BIOforum 31(2) (2008) 28-29
C. Vijayendran, A. Barsch, K. Friehs, K. Niehaus, A. Becker, E. Flaschel
Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling.
Genome Biology 9(4) (2008), R72. Doi:10.1186/gb-2008-9-4-r72
E. Flaschel
Can we expect a breakthrough in downstream processing of biotechnological products in the near future? (Editorial).
Chem. Eng. Tech. 31(6) (2008) 809
E. Flaschel
Aufarbeitung biotechnologischer Produkte - Steht eine Revolution bevor? (Editorial).
Chem. Ing. Tech. 80(6) (2008) 695
B. Sommer, B. Schmidt, K. Friehs, E. Flaschel
Extrazelluläre Produktion und Affinitätsaufreinigung einer rekombinanten Ribonuclease mit Escherichia coli.
Chem. Ing. Tech. 80(6) (2008) 839-845
N. Streitner, C. Voß, E. Flaschel
Reverse micellar extraction systems for the purification of pharmaceutical grade plasmid DNA.
J. Biotechnol. 131(2) (2007) 188-196
C. Voß
Production of plasmid DNA for pharmaceutical use.
Biotechnol. Ann. Rev. 13 (2007) 201-222
C. Voß
Foreword.
J. Chromatogr. A 1161 (2007) 1
U. Beshay, G. Miksch, K. Friehs, E. Flaschel
Increasing the secretion ability of the kil gene for recombinant proteins in Escherichia coli by using a strong stationary phase promoter.
Biotechnol. Lett. 29 (2007) 1893-1901
M. Blaesen, K. Friehs, E. Flaschel
Recycling of bacterial biomass in a process of L-threonine production by means of a recombinant strain of Escherichia coli.
J. Biotechnol. 132(4) (2007) 431-437
C. Vijayendran, S. Burgemeister, K. Friehs, K. Niehaus, E. Flaschel
2DBase: 2D-PAGE database of Escherichia coli.
Biochem. Biophys. Res. Comm. 363(3) (2007) 822-827
N. Wei, J. You, K. Friehs, E. Flaschel , T. W. Nattkemper
An in situ probe for on-line monitoring of cell density and viability on the basis of dark field microscopy in conjunction with image processing and supervised machine learning.
Biotechnol. Bioeng. 97(6) (2007) 1489-1500; DOI: 10.1002/bit.21368
N. Wei, J. You, K. Friehs, E. Flaschel , T. W. Nattkemper
In situ dark field microscopy for on-line monitoring of yeast cultures.
Biotech. Letters 29(3) (2007) 373-378; DOI 10.1007/s10529-006-9245-x
O. Roeva, T. Pencheva, S. Tzonkov, M. Arndt, B. Hitzmann, S. Kleist, G. Miksch, K. Friehs, E. Flaschel
Multiple Model Approach to Modelling of Escherichia coli Fed-batch
Cultivation Extracellular Production of Bacterial Phytase.
E. J. Biotechnol. 540 (2007)
C. Vijayendran, T. Polen, V.F. Wendisch, K. Friehs, E. Flaschel
The plasticity of global proteome and genome expression analysed in closely
related W3110 and MG1655 strains of a well-studied model organism, Escherichia coli-K12.
J. Biotechnol. 128(4) (2007) 747-761
U. Beshay, G. Miksch, K. Friehs, E. Flaschel
Improved ß-Glucanase Production by Recombinant Escherichia coli Strain
Using a Zinc-Ion Supplemented Medium.
Eng. Life Sci. 7(3) (2007) 253-258
U. Beshay, G. Miksch, E. Flaschel
Improvement of a ß-glucanase activity test by taking into account
the batch reactor balance of the test system.
Bioprocess Biosyst. Eng. 30 (2007) 251-259
R. Ulber, A. Liese, D. Sell, E. Flaschel
Entwicklung der Weißen Biotechnologie in der deutschen Hochschullandschaft
in Kooperation mit der Industrie.
Weiße Biotechnologie, Industrie im Umbruch. S. Heiden, H. Zinke (Hrsg.), BIOCOM AG, Berlin 2006
M. Blaesen, E. Flaschel, K. Friehs
Produktintegrierter Umweltschutz am Beispiel der Rückführung
bakterieller Biomasse.
Chem. Ing. Tech. 79(3) (2006) 267-272
E. Flaschel
Reactor performance in the presence of catalyst deactivation.
Eng. Life Sci. 6(2) (2006) 131-138
M. Blaesen, E. Flaschel, K. Friehs
Sustainable production: Recycling of bacterial biomass resulting
from a fermentation process with Klebsiella planticola.
Chem. Biochem. Eng. Q. 20(3) (2006) 263-268
C. Voß, D. Lindau, E. Flaschel
Production of recombinant RNase Ba and its application in
downstream-processing of plasmid DNA for pharmaceutical use.
Biotechnol. Prog. 22(3) (2006) 737-744
M. Arndt, S. Kleist, G. Miksch, K. Friehs, E. Flaschel, J. Trierweiler, B. Hitzmann
A feedforward-feedback substrate controller basded on a
Kalman filter for a fed-batch cultivation of
Escherichia coli producing phytase
Comp. Chem. Eng. 29 (2005) 1113-1120
E. Flaschel
Weiße Biotechnologie: Technologie mit Zukunft (Editorial)
Chem.-Ing.-Tech. 77(1-2) (2005) 3
J.M. Risse, A. Pühler, E. Flaschel
Production of N-acetyl-phosphinothricin: A substance used for
inducing male sterility in transgenic plants
Eng. Life Sci. 5(1) (2005) 38-45
G. Miksch, F. Bettenworth, K. Friehs, E. Flaschel, A. Saalbach, T. Twellmann, T. Nattkemper
Libraries of synthetic stationary-phase and stress promoters
as a tool for fine-tuning of expression of recombinant proteins in Escherichia coli
J. Biotechnol. 120 (2005) 25-37
G. Miksch, F. Bettenworth, K. Friehs, E. Flaschel
The sequence upstream of the -10 consensus sequence modulates
the strength and induction time of stationary-phase and stress
promoters in Escherichia coli
Appl. Microbiol. Biotechnol. (2005) 1-9
E. Flaschel, D. Sell
Charme und Chancen der Weißen Biotechnologie
Chem.-Ing. Tech. 77(9) (2005) 1298-1312
G. Miksch, F. Bettenworth, K. Friehs, E. Flaschel, A. Saalbach. T. Twellmann, T. Nattkemper
A rapid reporter system using GFP as a reporter protein
for identification and screening of synthetic stationary-phase
promoters in Escherichia coli
A. Hasche, C. Voß
Immobilisation of a repressor protein
for binding of plasmid DNA
J. Chromatogr. A 1080 (2005) 76-82
C. Voß, T. Schmidt, M. Schleef
From bulk to delivery: Plasmid manufacturing and storage
In: M. Schleef (Ed.), DNA-Pharmaceuticals, Wiley-VCH, Weinheim, Germany
C. Voß, T. Schmidt, M. Schleef, K. Friehs, E. Flaschel
Effect of ammonium chloride on plasmid DNA production
in high cell density batch culture for pharmaceutical use
J. Chem. Technol. Biotechnol. 79 (2004) 57-62
C. Voß
Innovative Prozessstrategien zur Herstellung von Plasmid-DNA als Wirkstoff
BIOforum 9 (2004) 38-39
S.-I. Han, K. Friehs, E. Flaschel
Cultivation of Dictyostelium discoideum on an improved
synthetic medium in a conventional bioreactor
Proc. Biochem. 39(5) (2004) 585-589
Y. Lu, U. Beshay, K. Friehs, E. Flaschel
Mass production of Dictyostelium discoideum in homogeneous
and heterogeneous cultivation systems
Proc. Biochem. 39(12) (2004) 1859-1870
Y. Lu, J.C. Knol, M.H.K. Linskens, K. Friehs, P.J.M. van Haastert, E. Flaschel
Production of the soluble human Fas ligand by means of
Dictyostelium discoideum cultivated on a synthetic medium.
J. Biotechnol. 108(3), (2004) 243-251
S.-I. Han, K. Friehs, E. Flaschel
Improvement of a synthetic medium for Dictyostelium discoideum.
Proc. Biochem. 39(8) (2004) 925-930
Y. Lu, J.C. Knol, M.H.K. Linskens, K. Friehs, P.J.M. van Haastert, E. Flaschel
Cultivation of immobilized Dictyostelium discoideum
for the production of soluble human Fas ligand.
Appl. Microbiol. Biotechnol. 65 (2004) 547-552
K. Friehs, E. Flaschel, G. Miksch, S. Kleist, B. Hitzmann, M. Arndt
Sekretion rekombinanter Phytase bei Escherichia coli.
BIOforum 26(4) (2003) 208-209
Kleist S; Miksch G; Hitzmann B; Arndt M; Friehs K; Flaschel E (2003)
Optimization of the extracellular production of a bacterial phytase with
Escherichia coli by using different fed-batch fermentation strategies
Appl. Microbiol Biotechnol 61 456-62
U. Beshay, K. Friehs, A.E.-M. Azzam, E. Flaschel
Cultivation of Dictyostelium discoideum in immobilized form by colonization of porous supports.
Proc. Biochem. 38 (2003) 1521-1529
C. Voß, T. Schmidt, M. Schleef, K. Friehs, E. Flaschel
Production of supercoiled multimeric plasmid DNA for biopharmaceutical application.
J. Biotechnol. 105 (2003) 205-213
W. Walther, U. Stein, C. Voß, T. Schmidt, M. Schleef, P.M. Schlag
Long term storage and stability analysis of naked DNA:
impact on non-viral in vivo gene transfer
Anal. Biochem. 318 (2003) 230-235
M. Stephan, U. Beshay, K. Friehs, E. Flaschel
Influence of medium composition on growth behaviour of Dictyostelium discoideum
for cultivation on axenic media.
Proc. Biochem. 39(3) (2003) 333-343
U. Beshay, G. Miksch, K. Friehs, E. Flaschel
Production of a bacterial b-glucanase by expression in Escherichia coli and
simultaneous adsorption on a metal chelate affinity resin.
Arab J. Biotechnol. 6(2) (2003) 187-194
U. Beshay, K. Friehs, A.E.-M. Azzam, E. Flaschel
Analysis of the behaviour of Dictyostelium discoideum in immobilized
state by means of continuous cultivation.
Bioproc. Biosyst. Eng. 26 (2003)117-122
G. Miksch, S. Kleist, B. Hitzmann, M. Arndt, K. Friehs, A. Cordes, E. Flaschel
Produktion der Phytase von Escherichia coli.
Im Sonderheft: Nachhaltige Biokatalyse
transkript 9 (2003) 85-88
K. Friehs (2003)
Plasmid copy number and plasmid stability.
Adv. Biochem Eng Biotechnol 86 (2003)
M. Schleef, T. Schmidt, K. Friehs, E. Flaschel
Plasmid DNA Manufacturing. In: Manufacturing of Gene Therapeutics.
G. Subramanian (Hrsg.). Kluwer Academic / Plenum Publishers, New York 2002
K. Friehs, J.M. Risse, F. Schierl, E. Flaschel
Herstellung von Mediumskomponenten aus mikrobieller Biomasse.
Freiberger Forschungshefte A 866 (2002) 112-124
G. Miksch, S. Kleist, K. Friehs, E. Flaschel
Overexpression of the phytase from Escherichia coli and its extracellular production in bioreactors.
Appl. Microbiol. Biotechnol. 59 (2002) 685-694
J. Hettwer, H. Oldenburg, E. Flaschel
Enzymic routes to dihydroxyacetone phosphate or immediate precursors.
J. Molec. Catal. B: Enzymatic 19-20 (2002) 215-222
W. Walther, U. Stein, I. Fichtner, C. Voß, T. Schmidt, M. Schleef, T. Nellessen, P.M. Schlag
Intratumoral low volume jet-injection for efficient nonviral gene transfer.
. Mol. Biotechnol. 21 (2002) 105-115
M. Schleef, C. Voß, T. Schmidt
DNA drugs - production and quality assurance.
Eng. Life Sci. 2 (2002) 157-160
E. Flaschel
Proteinaufarbeitung mit Hilfe gentechnischer Methoden.
GIT Separation 21(1) (2001) 18-21
K. Schröter, E. Flaschel, A. Pühler, A. Becker
Xanthomonas campestris pv. campestris secretes the endoglucanases ENGXCA and ENGXCB:
construction of an endoglucanase-deficient mutant for industrial xanthan production.
Appl. Microbiol. Biotechnol. 55(6) (2001) 727-733
G. Miksch, E. Flaschel
Secretion of homologous and heterologous recombinant proteins in Escherichia coli and other
Gram-negative bacteria
by using a new secretion system.
In: Recombinant protein production with prokaryotic and eukaryotic cells
A comparative view on host physiology. O.-W. Merten et. al. (Hersg.),
Kluwer Academic Publishers Group, Dordrecht, The Netherlands 2001
J.M. Risse, K. Friehs, E. Flaschel
Recycling of Biomass Resulting from Fermentation Processes with Bacillus licheniformis.
Chem. Eng. Technol. 24 (Eng. Life Sci. 1) (2001) 141-145
J.M. Risse, K. Friehs, E. Flaschel
Biomasserückführung am Beispiel Bacillus licheniformis.
Tech. 72 (2000) 750-754
M. Schleef, T. Schmidt, E. Flaschel
Plasmid DNA for Pharmaceutical Applications. In Development and Clinical Progress of DNA Vaccines.
F. Brown, K. Cichutek, K. Robertson (Hrsg.) Karger, Basel. Dev. Biol. 104 (2000) 25-31.
Schmidt, T., Schleef, M., Voß, C., Flaschel, E. (2000)
CGE-Analyse von Plasmid-DNA für klinische und veterinär-medizinische Applikationen.
BIOforum 12, 877-878
T. Schmidt, K. Friehs, M. Schleef, C. Voss, E. Flaschel
Quantitative Analysis of Plasmid Forms by Agarose and Capillary Gel Electrophoresis.
Anal. Biochem. 274 (1999) 235-240
T. Schmidt, M. Schleef, K. Friehs, E. Flaschel
Hochzelldichtefermentation zur Gewinnung von Plasmid-DNA für Gentherapie und genetische Impfung
BIOforum 22(4) (1999) 174-177
Miksch, R. Neitzel, K. Friehs, E. Flaschel
High level expression of a recombinant protein in Klebsiella planticola owing
to induced secretion into the culture medium
Appl. Microbiol. Biotechnol. 51 (1999) 627-632
R. Baier, K. Schiene, B. Kohring, E. Flaschel, K. Niehaus
Alfalfa and tobacco cells react differently to chitin oligosaccharides
and Sinorhizobium meliloti nodulation factors
Planta (1999)
A. Margot, E. Flaschel, A. Renken
Development of a continuously operated reactor for the limited hydrolysis of whey protein
by trypsin Process Biochem. 33(2) (1998) 125-131
F.-U. Huneke, E. Flaschel
Behaviour of liquid/liquid/solid three-phase fixed bed reactors
J. Chem. Technol. Biotechnol. 71 (1998) 213-222
K. Friehs, F. Schierl, E. Flaschel
Aufbereitung bakterieller Biomasse zwecks Rückführung in Fermentationsprozesse
Chem.-Ing.-Tech. 70 (1998) 435-437
E. Flaschel, L. Ebmeier
Stabilization of a-Chymotrysin by DMSO.
In Stability and Stabilization of Biocatalysts, A. Ballesteros, F.J. Plou, J.L. Iborra, P.J. Halling (Eds.),
pp. 223-228, Elsevier, Amsterdam, 1998, Progress Biotechnol. 15 (1998) 223-228.
E. Flaschel, L. Poppenborg, R. Neitzel, G. Miksch, K. Friehs
Affinitätstrennverfahren zur Gewinnung rekombinanter Proteine
BioTec 9(5/6) (1998) 26-29
L. Poppenborg, K. Friehs, E. Flaschel
The green fluorescent proteinis a versatile reporter for bioprocess monitoring.
J. Biotech. 58 (1997) 79-88
B. Kohring, R. Baier, K. Niehaus, A. Pühler, E. Flaschel
Production of Nodulation Factors by Rhizobium meliloti:Fermentation, Purification
and Characterization of Glycolipids.
Glycoconjugate J. 14 (1997) 963-971
A. Margot, E. Flaschel, A. Renken
Empirical Kinetic Models for Tryptic Whey-Protein Hydrolysis.
Process Biochem. 32(3) (1997) 217-223
G. Miksch, R. Neitzel, E. Fiedler, K. Friehs, E. Flaschel
Extracellular production of beta-glucanase by E. coli under different cultivation
conditions in shake cultures and bioreactors
Appl. Microbiol. Biotechnol. 47 (1997) 120-126
K. Niehaus, R. Baier, B. Kohring, E. Flaschel, A. Pühler
Symbiotic suppression of the Medicago sativa plant defence system
by Rhizobium meliloti oligosaccharides.
NATO ASI Ser. G 39 (1997) 111- 114
G. Miksch, E. Fiedler, P. Dobrowolski & E. Flaschel
Construction of transposons mediating the controlled secretion of
heterologousperiplasmic proteins into the culture medium, their
transposition in Acetobacter methanolicus and secretion
of a Bacillus hybridbeta-glucanase.
Appl. Microbiol. Biotechnol. 47 (1997) 530-536
E. Flaschel
Stoffumwandlung mit Enzymen.
Forschung an der Universität Bielefeld 13(1996) 28-33
M. Hentsch, P. Warnery, A. Renken, E. Flaschel
Study of the Simultaneous Partitioning of Proteins and Surfactant in Reverse
Micellar Two-Phase Systems - Potential Impact on Purification Efficiency.
Bioseparation 6(2) (1996) 67-76
E. Flaschel, E.R. Andriamboavonjy, A. Renken
Transfer and Disproportionation Reaction of the Cyclodextrin Glucanotransferase
of Klebsiella pneumoniae.
In Proceedings of the 8th International Cyclodextrin Symposium
J. Szejtli, L. Szente (Eds.), pp. 45-50
Kluwer Academic Publishers, Amsterdam, 1996
T. Schmidt, K. Friehs, E. Flaschel
Rapid Determination of Plasmid Copy Number.
J. Biotechnol. 49 (1996) 219-229
E. Flaschel, A. Margot, M. Dohmen, A. Renken
Conversion-space time profiles of stirred tank reactors continuously fed with
reactants and catalyst under conditions of strong catalyst deactivation.
FChem. Eng. Sci. 50(7) (1995) 1143-1147
M. Hentsch, E. Flaschel, A. Renken
Radiolabeled AOT for Studies of the Partitioning of the Surfactant
During Protein Extraction by Means of Reverse Micellar Two-Phase Systems.
J. Radioanal. Nucl. Chem. 19 (1995) 201-208
A. Margot, E. Flaschel, A. Renken
Continuous Monitoring of Enzymatic Whey Protein Hydrolysis.
Correlation of Base Consumption with Soluble Nitrogen Content
Process Biochem. 29 (1994) 257-262
L. Poppenborg, E. Flaschel
Affinity Extraction of Proteins by means of Reverse Micellar Phases
Containing a Metal-Chelating Surfactant.
Bioseparation 6(2) (1996) 67-76
E. Flaschel, T. Schäffer
New Evidence for Dimerization-Dependence of the Activity of Candida rugosa Lipase.
Biocatalysis 9 (1994) 241-248
F.-U. Huneke, E. Flaschel
Zur Phasenverteilung in Flüssig-Flüssig-Festbettreaktoren.
Chem.-Ing.-Tech. 66(12) (1994) 1649-1651
V. Schmidt, E. Flaschel, A. Renken
The Use of Chelating Resin for the Separation and Recovery of Heavy Metals from Industrial Wastewater.
In : Advances in Recovery and Recycling, Concepts and Technology,
Vol. III,pp. 217-224, M.E. Hestock, H.R. Skov (Eds.), Copenhagen : Hexagon Ltd. 1993
E. Flaschel, K. Friehs
Improvement of Downstream Processing of Recombinant Proteins by Means of Genetic Engineering Methods.
Biotech. Adv. 11 (1993) 31-78
S. Crelier, A. Margot, E. Flaschel, A. Renken
Determination of Partition Coefficients of Labile Compounds Subject to Dissociation Extraction.
Biocatalysis 8 (1993) 59-71
K. Friehs, K.F. Reardon
Parameters influencing the productivity of recombinant E. coli cultivations.
Adv. Biochem. Engin. Biotechnol. 48 (1993) 53-78, Springer Berlin
C. Moresoli, P. Zaza, E. Flaschel, A. Renken
Transesterification of Phenylalanine by means of Chymotrypsin in the
Presence of Dimethylsulfoxide.
Biocatalysis 5 (1992) 203-211
C. Moresoli, E. Flaschel, A. Renken
The Kinetics of Transesterification by a-Chymotrypsin of a Racemic Mixture
of Phenylalanine Propyl Ester with 1,4-Butanediol.
Biocatalysis 5 (1992) 213-231
A. Margot, C. Richoz, E. Flaschel, A. Renken
Einfluß der Trypsin-Desaktivierung auf die Hydrolyse von Molkeproteinen.
Chem.-Ing.-Tech. 64(6) (1992) 551-553
E. Flaschel, S. Crelier, K. Schulz, F.-U. Huneke, A. Renken
Process development for the optical resolution of phenylalanine by means of
chymotrypsin in a liquid-liquid-solid three-phase system.
In : Biocatalysisin Non-Conventional Media, J. Tramper et al. (Eds.),
pp. 163-170,Amsterdam : Elsevier Science Publishers 1992, (Progr. Biotechnol. 8(1992) 163-170)
E. Flaschel : Enzyme Kinetics and Reactor Design
in : BiocatalyticProduction of Amino Acids and Derivatives, J. D. Rozzell, F. Wagner(Edn.),
pp. 321-407, New York: Hanser Publishers, 1992
V. Schmidt, E. Flaschel, A. Renken
Chelatharze zur adsorptiven Abtrennung und Rückgewinnung von Schwermetallen aus Abwässern,
In : Verfahrenstechnik der mechanischen, thermischen,
chemischen und biologischen Abwasserbehandlung,
Preprints Band 2, pp. 133-137, GVC-Kongreß, Düsseldorf : VDI-GVC 1992
M. Hentsch, P. Menoud, L. Steiner, E. Flaschel, A. Renken
Optimization of the surfactant (AOT) concentration in a reverse micellar extraction process.
Biotechnol. Techniques 6(4) (1992) 359-364
M. Hentsch, P. Menoud, E. Flaschel, A. Renken
The effect of temperature on the kinetics of a reverse micellar protein extraction process.
Biotechnol. Techniques 6(5) (1992) 432-428
S. Crelier, A. Renken, E. Flaschel
Enzymatic Reaction in a Three Phase Liquid-Liquid-Solid Catalyst System -
Application to the Optical Resolution of Phenylalanine.
Swiss Chem 13(1) (1991) 7-12
S. Crelier, A. Renken, E. Flaschel
Enzymatic Reaction in a Three Phase Liquid-Liquid-Solid Catalyst System -
Application to the Optical Resolution of Phenylalanine.
Swiss Biotech 9(1) (1991) 7-11
C. Moresoli, E. Flaschel, A. Renken
Transesterification of Phenylalanine by means of Chymotrypsin in a
Continuous Fixed Bed Reactor.
Enzyme Microb. Technol. 13(9) (1991) 703-707
E. Flaschel
Technologie enzymatique
In : Guide de la technique 2 : Les Matériaux,Chap. 26, pp. 205-209,
Lausanne : Presses polytechniques et universitairesromandes 1991
E. Flaschel, A. Renken
The Behaviour of the Candida rugosa Lipase in the Presence of Soluble Substrates.
GBF Monograph Series 16 (1991) 349-352
C. Metzdorf, P.C. Singh, E. Flaschel, A. Renken
Effect of Static Mixers on Expansion and Axial Dispersion of Liquid in Fluidized Beds
at Low Reynolds Number
Chem. Eng. Comm. 106 (1991) 43-55
chemischen und biologischen Abwasserbehandlung,
E. Andriamboavonjy, E. Flaschel, A. Renken
Separation of functionalized dextrins by reversed-phase high-performance liquid chromatography.
J. Chromatogr. 587 (1991) 288-291
P.K.R. Kumar, H.-E. Maschke, K. Friehs, K. Schügerl
Strategies for improving plasmid stability in genetically modified bacteria in bioreactors.
Trends in Biotechnology 9 (1991) 279-284
C. Stiegelmeier, K. Friehs, K. Schügerl
Inactivation of recombinant microorganisms. Upstream and Downstream.
Processing in Biotechnology III, Dec. 9-10 1991, Antwerpen, Belgique
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Injection unit including a syringe, needle and a membrane filter with adsorbed drug for genetic immunization
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Method for producing homogeneous nucleic acid multimers for use in pharmaceutical compositions.
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Voß, C. (2002).
Method for the production of nucleic acids.
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Biomass production for the isolation of covalently closed circular plasmid DNA.
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Method for treatment of biomass from biological processes and use of the obtained products.
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