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:: DNA Regulatory Elements ::
Transcriptional regulation is mediated by the interaction between transcription
factors and their DNA binding sites which are called cis-regulatory
elements. Among these elements are core promoter elements such as TATA box and
initiator and promoter-proximal elements such as CAAT box and GC box, elements
from enhancer regions which mediate positively regulated transcription,
silencer elements which interact with repressors, and other reponse elements
such as the heat shock response element.
Polycomb/Trithorax response elements (PRE/TREs) are epigenetic switchable
elements. They maintain the previously determined transcriptional state of
their associated genes over many cell generations, thus ensuring a memory of
transcriptional history. The Polycomb group (PcG) proteins mediate
transcriptional repression while the trithorax group (trxG) proteins act
antagonistically, maintaining activation.
| current projects |
Comparative PRE/TRE analysis 
Comparative analysis of Drosophila
Polycomb/Trithorax Response Elements
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| past projects |
PREdictor
Genome-wide prediction of Polycomb/Trithorax
Response Elements in Drosophila melanogaster
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