:: Computational RNomics ::

Our focus in this area is the analysis of microRNAs and their targets. MicroRNAs (miRNAs) are short RNAs (around 22nt) that post-transcriptionally regulate the expression of target genes by binding to the target mRNAs. In cases of perfect or near-perfect complementarity between miRNA and target site, the target mRNA is cleaved and subsequently degraded. In cases of weaker complementarity, the translation of the mRNA into protein is inhibited. The miRNA pathway constitutes a complex regulatory mechanism whose importance and even existence has been recognised only recently.

current projects

Arabidopsis miRNA targets 
Prediction and experimental validation of Arabidopsis microRNA targets

Human miRNA targets 
Prediction and experimental validation of human microRNA targets

past projects

RNAhybrid 
Fast and effective prediction of microRNA/target duplexes

Fri Dec 19 10:54:56 CET 2014