:: DNA Regulatory Elements ::

Transcriptional regulation is mediated by the interaction between transcription factors and their DNA binding sites which are called cis-regulatory elements. Among these elements are core promoter elements such as TATA box and initiator and promoter-proximal elements such as CAAT box and GC box, elements from enhancer regions which mediate positively regulated transcription, silencer elements which interact with repressors, and other reponse elements such as the heat shock response element.

Polycomb/Trithorax response elements (PRE/TREs) are epigenetic switchable elements. They maintain the previously determined transcriptional state of their associated genes over many cell generations, thus ensuring a memory of transcriptional history. The Polycomb group (PcG) proteins mediate transcriptional repression while the trithorax group (trxG) proteins act antagonistically, maintaining activation.

current projects

Comparative PRE/TRE analysis 
Comparative analysis of Drosophila Polycomb/Trithorax Response Elements

past projects

Genome-wide prediction of Polycomb/Trithorax Response Elements in Drosophila melanogaster

Fri Dec 19 10:54:56 CET 2014